tumor protein p53
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]
Gene aliases
BCC7,
LFS1,
TRP53
Chromosome
17
Map location
17p13.1
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for TP53
| Domains | |
|---|---|
| PTMs | |
| Protein entries | |
| Sequence variants | |
| Cell lines/tissues | |
| Pathways involved in | |
| Protein-Protein Interactions |
Sequence variants for TP53
List of cell lines/tissues that have TP53 sequence variants
List of pathways where TP53 is involved
| Pathway name | Pathway source |
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Protein-Protein Interaction Network for TP53
Network key
Number of sequence variations per gene
Protein identification for TP53
Browse by protein identification methods
| Identification method | Quantitative data available |
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