SMAD family member 2
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Gene aliases
JV18,
JV18-1,
MADH2,
MADR2,
hSMAD2
Chromosome
18
Map location
18q21.1
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for SMAD2
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Sequence variants for SMAD2
List of cell lines/tissues that have SMAD2 sequence variants
List of pathways where SMAD2 is involved
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Protein-Protein Interaction Network for SMAD2
Network key
Number of sequence variations per gene
Protein identification for SMAD2
Browse by protein identification methods
| Identification method | Quantitative data available |
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