neuroblastoma RAS viral (v-ras) oncogene homolog
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
Gene aliases
ALPS4,
CMNS,
N-ras,
NCMS,
NS6
Chromosome
1
Map location
1p13.2
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for NRAS
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| PTMs | |
| Protein entries | |
| Sequence variants | |
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Sequence variants for NRAS
List of cell lines/tissues that have NRAS sequence variants
List of pathways where NRAS is involved
| Pathway name | Pathway source |
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Protein-Protein Interaction Network for NRAS
Network key
Number of sequence variations per gene
Protein identification for NRAS
Browse by protein identification methods
| Identification method | Quantitative data available |
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