F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Gene aliases
AGO,
CDC4,
FBW6,
FBW7,
FBX30,
FBXO30,
FBXW6,
SEL-10,
SEL10,
hCdc4
Chromosome
4
Map location
4q31.3
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for FBXW7
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Sequence variants for FBXW7
List of cell lines/tissues that have FBXW7 sequence variants
List of pathways where FBXW7 is involved
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Protein-Protein Interaction Network for FBXW7
Network key
Number of sequence variations per gene
Protein identification for FBXW7
Browse by protein identification methods
| Identification method | Quantitative data available |
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