catenin (cadherin-associated protein), beta 1, 88kDa
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009]
Gene aliases
CTNNB,
armadillo
Chromosome
3
Map location
3p21
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for CTNNB1
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Sequence variants for CTNNB1
List of cell lines/tissues that have CTNNB1 sequence variants
List of pathways where CTNNB1 is involved
| Pathway name | Pathway source |
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Protein-Protein Interaction Network for CTNNB1
Network key
Number of sequence variations per gene
Protein identification for CTNNB1
Browse by protein identification methods
| Identification method | Quantitative data available |
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