adenomatous polyposis coli
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]
Gene aliases
BTPS2,
DP2,
DP2.5,
DP3,
PPP1R46
Chromosome
5
Map location
5q21-q22
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for APC
| Domains | |
|---|---|
| PTMs | |
| Protein entries | |
| Sequence variants | |
| Cell lines/tissues | |
| Pathways involved in | |
| Protein-Protein Interactions |
Sequence variants for APC
List of cell lines/tissues that have APC sequence variants
List of pathways where APC is involved
| Pathway name | Pathway source |
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Protein-Protein Interaction Network for APC
Network key
Number of sequence variations per gene
Protein identification for APC
Browse by protein identification methods
| Identification method | Quantitative data available |
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