complement component 4A (Rodgers blood group)
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Gene aliases
C4,
C4A2,
C4A3,
C4A4,
C4A6,
C4AD,
C4S,
CO4,
RG
Chromosome
6
Map location
6p21.3
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for C4A
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Sequence variants for C4A
List of cell lines/tissues that have C4A sequence variants
List of pathways where C4A is involved
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Protein-Protein Interaction Network for C4A
Network key
Number of sequence variations per gene
Protein identification for C4A
Browse by protein identification methods
| Identification method | Quantitative data available |
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